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Estrogen and progesterone are thought to play a role, but melasma should not be described as the result of one hormone being too high. Its biology involves hormonal sensitivity, ultraviolet exposure, melanocyte activity and genetic factors

-MSH binds to different melanocortin receptors to produce different effects, including the following: Increases melanin production by binding to the melanocortin 1 receptor (MC1R), stimulating the production of different enzymes, including tyrosinase

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