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Researchers suggest that elevated gut pH, gut dysbiosis (i.e., a higher Firmicutes : Bacteroidetes ratio), obesity, or malabsorption might increase fecal SCFA, such as butyrate, which could have potential neurotoxic effects [25, 45, 46]

For example, VSG surgery enhances resting-state functional connectivity between the hippocampus and the insula [41] and between the dorsolateral PFC and the anterior cingulate, with these outcomes accompanied by dampened cravings for high calorie foods [42] and reduced fasting levels of ghrelin [41,42]

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