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Studies show that inhibiting nicotinamide Nmethyltransferase (NNMT) enhances metabolic health by reducing adipose tissue accumulation, improving insulin sensitivity, and promoting better energy utilization

It leads to dullness, clogged pores, uneven texture, and fine lines

One very recent study of a TREM2 agonistic antibody in the cuprizone model reported enhanced myelin debris uptake and degradation, together with improved remyelination (Cignarella et al., Another approach could involve targeting lipid metabolism, as the uptake of too much cholesterol-rich myelin debris converts microglia into cells with a proinflammatory profile