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Medicare coverage for GLP-1s specifically for weight loss has also been limited and policy dependent
CVOTs specifically evaluate the incidence of major adverse cardiovascular events (MACE), which includes CV mortality, non-fatal myocardial infarction, and non-fatal stroke, commonly known as 3-point MACE. Hospitalization for acute coronary syndrome, urgent revascularization procedures, and other possible endpoints such as hospitalization for angina or HF can also be incorporated into the CV outcome endpoints of interest
Lower GI rates than semaglutide at equivalent efficacy in SURPASS-2
Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance
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