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Red flags requiring urgent evaluation include hematemesis, intractable vomiting leading to dehydration, severe abdominal pain or distention, and signs of gastrointestinal bleeding

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For comparisons of feature sets in models, either metabolomics or knowledge features were replaced with additional PC features to create the transcriptomics-only models with an equivalent number of features (i.e., a mitochondrial classifier with the first 5 PCs and two MitoCarta score vectors as features is comparable to a transcriptomics-only classifier using the first 7 PCs as features)