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In cytotoxicity experiments, free curcumin frequently exhibited greater activity than its corresponding metal complexes, suggesting that coordination with certain metals may reduce its biological effectiveness

Acetyl l-carnitine has showed benefit towards improving attention for people with downs syndrome, Alzheimers disease and migraines, however one study has found it appears safe to use for people with ADHD but has no effect on the overall population, suggesting more studies take place for potential benefits for specific types of the disorder

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