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It has a number of side effects, but the most severe include: Pancreatitis Gallbladder issues Increased risk of low blood sugar Kidney problems Changes in vision Increased heart rate Severe allergic reactions Saxenda Saxenda is another injectable drug by Novo Nordisk and is used to treat obesity in children and adults, as well as treat weight loss in adults

Because of this, MOTS-c is being investigated as a treatment for obesity, diabetes, and even age-related frailty

Some report success maintaining weight through lifestyle changes alone, but most highlight a rapid return of hunger and weight regain if medication is stopped abruptly, underscoring the need for structured support when adjusting or discontinuing treatment

This is why fatigue on semaglutide and GLP-1 fatigue are so common