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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

GLP-1(936) is the product of GLP-1(7-36) degradation by DPP-4, and this process rapidly reduces the activity of GLP-1(7-36).35,256,257 Traditionally, GLP-1(936) was considered a metabolically inactive product of GLP-1, losing its primary function of regulating blood sugar.258 However, increasing research suggests that GLP-1(936) may have other physiological roles

References Vuorinen-Markkola H, Yki-Jrvinen H