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Clinical studies for other novel multi-targeted TKIs, such as ponatinib (AP24534), anlotinib (AL3818), and TPX-0046, are ongoing in advanced or metastatic MTC [3133]

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The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

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