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Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)
Its designed to mimic three key metabolic hormones : GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) Glucagon This makes it a triple agonist , meaning it activates three different hormone receptors that are involved in metabolism, appetite regulation, and fat burning
However, its especially appropriate for GLP-1 medication users because of slowed gastric emptying and the increased perception of satiety
AOD 9604 targets adipose tissue and promotes its efficient metabolism
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