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This leaves practitioners in a difficult position: acknowledging a promising safety signal while recognizing the profound limitations of unpublished data

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This leads to uncertainty behind the actual mechanism of Akkermansia supplementation, as far as whether Akkermansia actually stays in the body when administered, whether supplementation has only temporary or long-lasting effects, and if supplementation can aid the natural composition of Akkermansia or not

In addition, the astrocytic glutamine synthetase will convert ammonia and glutamate into glutamine, which in turn acts as an osmolyte and will increase cerebral volume [8]