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The expression of VE-cadherin (VE-Cad), an adherens junction protein and a key regulator of endothelial barrier function [77], was assessed in this model, showing cell elongation, which indicates the presence of a tight endothelial-like monolayer [43, 44]
Water 15 (5), 928
Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication
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