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VDAC2 is an important component of the mitochondrial apoptotic signaling cascade [203] and is activated by SNO [204]

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Their systemic anti-inflammatory effects, metabolic regulation, and influence on satiety and insulin sensitivity suggest they could help prevent the onset of multiple chronic conditions especially in high-risk populations

These results suggest that the experimental dosing strategy improved metabolic efficiency (as indicated by the lower RQ) and reduced mental and physical perception of effort