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Estrogen binds to estrogen receptors (ER-alpha and ER-beta)

In tumor cells, the apoptosis pathway is often impeded by various mechanisms, many of which contribute to intrinsic resistance to chemotherapy, the most prevalent anticancer therapy (104)

Weight loss is already part of the recommendations for many patients with arthritis, but our study may indicate that medication such as Wegovy could have a dual effect both through weight loss and by increasing GLP-1 levels in the joints, says Tue Wenzel Kragstrup

For adults with obesity (BMI over 30) or those with comorbidities- medically supervised injections may offer the best chances for lasting change