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Cell Mol Life Sci 78:74357449 Betin VM, Singleton BK, Parsons SF, Anstee DJ, Lane JD (2013) Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation

doi: 10.1007/s00223-018-0395-3

We calculated ALS-FRS-R decline, as (48 - ALS-FRS-R at interview) divided by (time from disease onset to interview in month), as marker of disease progression

Key Takeaway: Greying is often driven by an imbalance where oxidative waste (hydrogen peroxide) outweighs the bodys antioxidant defenses (glutathione and catalase)