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Studies done on isolated human middle cerebral arteries showed that after exposure to soluble particles from cigarette smoke, acetylcholine (ACh)-induced endothelium-dependent relaxation was reduced [83]
Second layer: Results from the in vitro experiments would be validated with exhaled breath analysis
Nicotine Replacement Therapy ( NRT ): A form of treatment for nicotine addiction that involves the use of products that deliver nicotine to the body, such as nicotine gum, patches, lozenges, inhalers, or nasal sprays, to help reduce withdrawal symptoms and cravings
The aim of NRT is to replace the nicotine from the smokeless tobacco to reduce withdrawal symptoms that individuals might experience in their attempt to stop smokeless tobacco use, thereby helping in the process towards abstinence 10
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