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The strongest clinical evidence: a 2019 randomized, double-blind 12-week trial in the British Journal of Dermatology (n=44) found 0.5% bakuchiol and 0.5% retinol produced comparable reductions in wrinkle surface area and hyperpigmentation, with retinol users reporting significantly more facial scaling and stinging

Intervention with SLE serum or interferon- (IFN-) reduced GPX4 expression and caused neutrophil death, while inhibition of IFN- restored neutrophil survival

Research indicates that this copper peptide actively stimulates collagen synthesis, promotes elastin production, and accelerates wound healing processes, making it a sought-after compound in both clinical dermatology and longevity science

World Neurosurg x 22:100328 Mohseni-Moghaddam P, Sadr SS, Roghani M, Arabzadeh S, Khamse S, Zamani E, Hosseini M, Moradi F (2019) Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid-induced epileptic rats by antioxidant activity and NLRP3/caspase-1 pathway inhibition