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The medicine should not be injected into a muscle or vein

A method for synthesizing semaglutide, which is characterized by comprising the following steps: (1) Preparation of compound 2: arg34GLP-1 (9-37) is taken as a starting material, side chain modification is carried out on 26-Lys of the Arg34GLP-1 (9-37) and the compound 1, acylation coupling reaction is carried out under certain reaction pH conditions, and solid is precipitated by adjusting isoelectric point of reaction liquid after post-treatment to obtain a compound 2

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Semaglutide obtained by the process of the present invention is having purity of greater than 90% by HPLC