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For the case of such a small molecule as niclosamide, (V m = 202.53.0 cm 3 , ACD/iLabs) and a low topological polar surface area of 95.15 2 (Drugbank), (where any value below 140 2 is considered hydrophobic enough to partition into the membrane interior), it is well within the parameters for membrane partitioning

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Italian Journal of Gastroenterology and Hepatology, 31 (5), 401407

doi: 10.1200/edbk_200241 Summary Keywords melanoma, melanoma progression, metastasis, signaling pathways, melanoma therapies Citation Eddy K, Shah R and Chen S (2021) Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities