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Avoid combining with NSAIDs, which may counteract its healing effects

But heres what we do know: Some people experience gastrointestinal side effects on tirzepatide, such as nausea, vomiting, diarrhea, or constipation Vitamin B12 supplementation is generally considered safe, but high doses might cause headache, nausea, or bowel changes Side effects for both usually improve with time as the body adjusts If youre curious about taking tirzepatide and B12 together or if you are unsure whether you may have nutritional deficiencies, talk to your provider before making any changes

This pain is usually mild and goes away as your body adjusts to the medication

This method puts B12 directly into the blood, avoiding digestion problems