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Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, achieved 24.2% weight loss in Phase 2 trials

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Although there is a correlation between the two variables, it is not significant enough to draw any definite conclusions about the existence of a small-study effect based on this analysis alone (p-value = 0.485 for the slope)

Other long-term trials designed to evaluate whether SGLT2 inhibitors have renal protective effects in participants with T2D, and without T2D but with or without chronic kidney disease and macroalbuminuria are ongoing (e.g., the Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE) study, NCT02065791