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Nature Reviews Endocrinology, 8, 728-42

The intensity may be slightly higher with Wegovy because it reaches a higher maintenance dose (2.4 mg vs Ozempics 12 mg)

Studies thus far suggest semaglutide is generally safe for long-term use, though its been linked to a higher risk of gallbladder issues with longer use

As a dual GIP/GLP-1 receptor agonist, tirzepatide works through additional pathways compared to pure GLP-1 agonists