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Those with asthma should also exercise caution as there are anecdotal reports (mostly with inhaled glutathione) of it triggering asthma attacks in susceptible individuals

The causal role of opioids in the syndrome of hypogonadism is unknown because the various medical, physical, lifestyle, and psychological stressors that may influence gonadal hormone levels have not been adequately controlled for in studies conducted to date (see ADVERSE REACTIONS)

As with any supplement, it's smart to start with a lower dose and gradually increase as your body adjusts

Redox-based regulation of signal transduction: principles, pitfalls, and promises