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Common symptoms include: Sharp or burning pain during or after passing stool Bright red blood on toilet paper or in the toilet bowl Itching or irritation around the anus A small visible crack or tear near the anal opening A small lump or skin tag near the fissure (in chronic cases) If these symptoms persist for more than two weeks, its important to see a gastroenterologist or colorectal specialist for proper evaluation

26 DNA damage or mutations develop to a certain extent, which exceeds the limit of self-repair, contributing to in situ carcinoma, where the pathological cells are confined within the ducts but have not yet invaded the surrounding tissues

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both carry the same FDA boxed warning for thyroid tumors