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Research has shown that GLP-1 agonists can lead to a significant reduction in caloric intake by acting on the brain's appetite centres, particularly the hypothalamus, to promote feelings of fullness and decrease the desire to eat
Despite growing evidence of benefit, barriers (eg, prescriber hesitancy, high costs, limited insurance coverage) persist
SELENOP contains two histidine-rich stretches in the N-terminal domain, which may bind to heparin (Hondal et al., 2001)
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