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Factors favouring transdermal absorption are high lipid solubility and a good regional blood supply to the site of application (therefore, the thorax and abdomen are preferred to limbs)

Most users report that gains in body composition and metabolic markers hold partially during the off period, particularly if diet and training remain consistent

It also suppresses free-radical damage and thus is a potent antioxidant

ROS are reported to cause oxidation of the catalytic cysteine residue at the active site of E1 and E2 enzymes and promote the formation of E1/E2-containing disulfide complexes, which prevents these enzymes from catalyzing ubiquitination [note: this would decrease levels of ubiquitin conjugates] (Hunter, 2007)