eye problems with semaglutide linked to risk of rare condition Ophthalmologic Manifestations from Semaglutide (Ozempic/Wegovy)

It also requires multiple doses throughout the day

Retatrutide is supplied as a lyophilized powder and should be reconstituted with bacteriostatic water (BAC water) immediately before use

doi:10.1002/jps.2600820407 Vargas F, Carbonell K, Camacho M (2003) Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug

Side effects what to expect The most common side effects are gastrointestinal and worst in the first 48 weeks (full breakdown in our side-effects guide): Nausea (around 40% of patients in week one usually settles) Constipation or diarrhoea Reflux / burping / "sulphur burps" Reduced appetite (the desired effect) Tiredness and dizziness especially if dehydrated Less common but more serious risks include pancreatitis, gallbladder disease, severe dehydration leading to acute kidney injury, and very rarely thyroid C-cell tumours (seen in rodents human relevance unclear, but the medicines are contraindicated in MEN2 and personal/family history of medullary thyroid cancer)