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Many authors discuss the inadequacy of guidelines when written based on general consensus and expert opinion, rather than on high-level clinical evidence, noting that case reports, retro/prospective studies, and observational studies, as is mostly what is currently available, are often insufficient to inform clinical practice (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)

These findings help inform how targeting multiple hormone pathways may affect appetite regulation and metabolism in controlled study settings

Phillips S, Donaldson L, Geisler K, Pera A, Kochar R

Post-interventional WHR analysis across five studies (423 participants