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While pharmaceutical GLP-1 agonists work through direct receptor stimulation, dihydroberberine appears to work through multiple complementary pathways, supporting not only GLP-1 production but also enhancing insulin sensitivity and reducing oxidative stress

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The PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes trial is a multicenter study evaluating GLP-1 RAs versus SGLT2i for both primary and secondary prevention of ASCVD in patients with T2DM [62]

Common side effects for both include mild injection-site reactions, transient water retention, and occasionally a 'flushing' sensation immediately after injection