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The GHK sequence also appears within the alpha-2(I) chain of type I collagen, leading to the hypothesis that collagen degradation at wound sites releases GHK fragments that then bind copper and signal for new collagen production, creating a self-repair feedback loop

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Resultantly, the protein could be misfolded or subjected to erratic post-translational modification, ultimately being more susceptible to proteolysis and other forms of degradation in the RBC (88)