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Skin sensitivity: an emerging signal Skin burning and abnormal touch sensitivity (dysesthesia) appears as a dose-related, reversible signal in two case series and post-market surveillance. Trials did not pre-specify it, and the tirzepatide label does not list it

Reconstituted peptides must be refrigerated at 2 to 8 degrees Celsius (standard refrigerator temperature)

The narrative format was selected to accommodate heterogeneous evidence spanning preclinical mechanisms, clinical trials, and translational barriers where systematic synthesis would be inappropriate

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