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Assay design considerations for amylin receptor and calcitonin receptor signaling studies Cagrilintide is frequently used in receptor research designs that examine response curves, kinetic profiles, and persistence over time under controlled assay conditions

A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR

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