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Certain peptides may not be appropriate, or may need to wait, for patients with active cancer or a recent history of certain cancers (particularly for growth-hormone-related peptides), uncontrolled cardiovascular disease, pregnancy or planned pregnancy, certain autoimmune conditions depending on the peptide, or a known sensitivity to peptide therapy in the past

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I, personally, have also noticed that I am a little more sore for the next couple of days after getting trigger point injections, but the increased soreness is worth the lasting results