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The alteration of the brain microenvironment can result in impaired protective properties of the BBB and can lead to CNS diseases (16, 20)

However, because the trial was designed to demonstrate the superiority of temozolomide, which was not achieved, the trial was left with a sample size that was inadequate to provide statistical proof of noninferiority.[34] Palliative local therapy Regional lymphadenectomy may be used as palliative care for melanoma that is metastatic to distant, lymph nodebearing areas

All samples were evaporated to dryness and resuspended in 150 L of water/acetonitrile (ACN) (90:10, v/v) containing 0.5% FA

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