Once phosphorylated, these transcription regulators could migrate into the nucleus of somatotroph cells, possibly impacting genes associated with growth hormone formation
The combination creates a context where AOD 9604s lipolytic effect is occurring simultaneously with GH-stimulated protein synthesis and recovery, theoretically allowing fat loss and lean mass preservation to happen in parallel
Other GLP-1R, GIPR, and glucagon receptor (GCGR) poly-agonists are in development and have been tested in phase 1 and phase 2 clinical trials, including GLP-1R/GCGR agonists, GLP-1R/GLP-2R agonists, and triple GLP-1R/GIPR/GCGR agonists (abstracts presented at the American Diabetes Association Annual Meeting in June, 2022 and (7))
Of 10 men whose metastatic cancers could be measured with imaging scans, five experienced tumor shrinkage by more than half, including one man whose cancer completely disappeared