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To be more specific, SF3B1 mutations at codon 625 are predominately associated with mucosal and uveal melanoma, while alterations at codon 700 are present across myeloid leukemia and chronic lymphocytic leukemia ( SF3B1 mutations are widely present in MM, it is poorly understood which genes alternatively spliced by mutant SF3B1 drive malignant transformation

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Cell proliferation was observed by measuring the absorbance at 450 nm