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It can increase resting heart rate, and patients with cardiovascular disease need to approach it cautiously

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10mg tirzepatide vial (lyophilized powder) Bacteriostatic water (not sterile water, not saline, not normal water) Sterile syringe for reconstitution (a 3ml syringe with a needle works well) Alcohol swabs (70% isopropyl alcohol pads) U-100 insulin syringes for dosing (29-31 gauge) Sharps container for disposal Clean, well-lit workspace A note on the water: you must use bacteriostatic water , not sterile water for injection

Unlike traditional GLP-1 receptor agonists, which are peptide-based molecules requiring injection, orforglipron represents a fundamental shift to small molecule engineering