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Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG , Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J

Thus, at the level of overall glucose homeostasis the AMPK-mediated activation of PDE4B will counter all of the cAMP-PKA-mediated effects in hepatocytes that are stimulated by glucagon as well as those exerted by epinephrine binding to hepatic 2 -adrenergic receptors